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World J Gastroenterol. Jun 21, 2014; 20(23): 7466-7472
Published online Jun 21, 2014. doi: 10.3748/wjg.v20.i23.7466
Published online Jun 21, 2014. doi: 10.3748/wjg.v20.i23.7466
Association of MYO9B gene polymorphisms with inflammatory bowel disease in Chinese Han population
Jing Hu, Qiao Mei, Jian Huang, Nai-Zhong Hu, Xiao-Chang Liu, Jian-Ming Xu, Department of Gastroenterology, the First Affiliated Hospital of Anhui Medical University, Key Laboratory of Gastroenterology of Anhui Province, Hefei 230022, Anhui Province, China
Author contributions: Hu J, Mei Q, Hu NZ and Xu JM designed the research; Hu J and Huang J performed the research; Huang J and Liu XC analyzed the data; Hu J wrote the paper; Xu JM revised the manuscript.
Correspondence to: Jian-Ming Xu, PhD, Professor, Department of Gastroenterology, the First Affiliated Hospital of Anhui Medical University, Key Laboratory of Gastroenterology of Anhui Province, Jixi Rd 218, Hefei 230022, Anhui Province, China. xujm1017@163.com
Telephone: +86-551-62922039 Fax: +86-551-63633742
Received: January 16, 2014
Revised: March 15, 2014
Accepted: April 21, 2014
Published online: June 21, 2014
Revised: March 15, 2014
Accepted: April 21, 2014
Published online: June 21, 2014
Core Tip
Core tip: An association between MYO9B gene polymorphisms and inflammatory bowel disease (IBD) in the Chinese Han population has not yet been confirmed. The authors aimed to explore the association of MYO9B gene polymorphisms with the clinical phenotypes and intestinal permeability of IBD in China. The results suggested that MYO9B gene polymorphisms may influence the sub-phenotypic expression of Crohn’s disease but failed to confirm an association between the MYO9B polymorphisms and intestinal permeability in Chinese Han IBD. These findings indicate that the MYO9B gene may differ among IBD patients of various races from various regions.