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World J Gastroenterol. Jun 21, 2014; 20(23): 7461-7465
Published online Jun 21, 2014. doi: 10.3748/wjg.v20.i23.7461
Published online Jun 21, 2014. doi: 10.3748/wjg.v20.i23.7461
Clinical significance of expression of tissue factor and tissue factor pathway inhibitor in ulcerative colitis
Hao-Lan He, Qian Li, Department of Gastroenterology, Central Hospital Affiliated to Shenyang Medical College, Shenyang 110024, Liaoning Province, China
Ji-Bin Zhang, Depatprtment of Endocrinology, The Seventh People's Hospital of Shenyang, Shenyang 110024, Liaoning Province, China
Author contributions: He HL and Li Q performed the majority of experiments, designed the study and wrote the manuscript; Zhang JB provided vital reagents and analytical tools in addition to providing financial support for this work.
Correspondence to: Dr. Hao-Lan He, Department of Gastroenterology, Central Hospital Affiliated to Shenyang Medical College, Tiexi District Seven South Road No.5, Shenyang 110024, Liaoning Province, China. hehaolan@163.com
Telephone: +86-24-85715200 Fax: +86-24-85715200
Received: April 7, 2014
Revised: May 7, 2014
Accepted: May 19, 2014
Published online: June 21, 2014
Revised: May 7, 2014
Accepted: May 19, 2014
Published online: June 21, 2014
Core Tip
Core tip: Recent research showed that tissue factor (TF) and tissue factor pathway inhibitor (TFPI) are associated with inflammatory reactions, and they are expressed in many kinds of tissue and cells. There are few reports about the relationship between TF and TFPI and ulcerative colitis (UC). In this study, we performed immunohistochemical staining for TF and TFPI expression in tissue of UC and normal colon, to determine their association with UC and their significances in pathogenesis. The study results suggest that TF and TFPI may play an important role in the pathogenesis of UC.