Meta-Analysis
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World J Gastroenterol. Jan 14, 2014; 20(2): 584-592
Published online Jan 14, 2014. doi: 10.3748/wjg.v20.i2.584
Chemotherapy for patients with gastric cancer after complete resection: A network meta-analysis
Ya-Wu Zhang, Yu-Long Zhang, Hui Pan, Feng-Xian Wei, You-Cheng Zhang, Yuan Shao, Wei Han, Hai-Peng Liu, Zhe-Yuan Wang, Sun-Hu Yang
Ya-Wu Zhang, Yu-Long Zhang, Hui Pan, Feng-Xian Wei, You-Cheng Zhang, Yuan Shao, Wei Han, Hai-Peng Liu, Zhe-Yuan Wang, Sun-Hu Yang, Department of General Surgery, Lanzhou University Second Hospital, Lanzhou 730030, Gansu Province, China
Author contributions: Zhang YW, Zhang YL and Zhang YC designed the research; Wei FX, Han W and Wang ZY performed the research; Pan H, Shao Y, Liu HP and Yang SH analyzed the data; Zhang YW, Zhang YL and Zhang YC wrote the paper.
Correspondence to: Dr. You-Cheng Zhang, Department of General Surgery, Lanzhou University Second Hospital, Cuiyingmen 82, Chengguan District, Lanzhou 730030, Gansu Province, China. zhangychmd@126.com
Telephone: +86-931-8942287 Fax: +86-931-8942287
Received: July 22, 2013
Revised: October 26, 2013
Accepted: November 1, 2013
Published online: January 14, 2014
Core Tip

Core tip: Although adjuvant chemotherapy after complete resection of gastric cancer is therapeutically useful, which of the many regimens is most effective? To date, no regimen has been clearly recommended as the standard procedure post-operation; therefore, we performed a network meta-analysis, which is a useful tool to summarize the different clinical trials and to evaluate the effectiveness of different chemotherapy regimens for patients after complete resection of gastric cancer. Based on our findings, the Tegafur regimen, especially S-1, is the first therapy that should be recommend to the patients to reduce overall mortality.