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©2014 Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. May 21, 2014; 20(19): 5808-5817
Published online May 21, 2014. doi: 10.3748/wjg.v20.i19.5808
Published online May 21, 2014. doi: 10.3748/wjg.v20.i19.5808
Intervention on toll-like receptors in pancreatic cancer
Juan Vaz, Roland Andersson, Department of Surgery, Clinical Sciences Lund, Skåne University Hospital Lund, Lund University, SE-221 85 Lund, Sweden
Author contributions: Vaz J collected the underlying material and wrote the initial draft of the manuscript; Andersson R and Vaz J designed the outline of the paper; Andersson R finalized and revised the manuscript; both authors have read and approved this final version.
Correspondence to: Roland Andersson, MD, PhD, Department of Surgery, Clinical Sciences Lund, Skåne University Hospital Lund, Lund University, SE-221 85 Lund, Sweden. roland.andersson@med.lu.se
Telephone: +46-461-72359 Fax: +46-461-72335
Received: November 8, 2013
Revised: February 19, 2014
Accepted: March 19, 2014
Published online: May 21, 2014
Revised: February 19, 2014
Accepted: March 19, 2014
Published online: May 21, 2014
Core Tip
Core tip: The combination of high mortality rates and a tremendously complex pathophysiology makes pancreatic ductal adenocarcinoma (PDA) an enormous challenge. We summarize the current knowledge about the importance of toll-like receptors (TLR) in PDA. Since both tumor and tumor-related cells express TLRs, intervention on TLR-related pathways may represent future candidates for therapy.