Published online May 21, 2014. doi: 10.3748/wjg.v20.i19.5639
Revised: January 19, 2014
Accepted: March 6, 2014
Published online: May 21, 2014
Core tip:Helicobacter pylori (H. pylori) infection is one of the most common bacterial infections in humans. The mode of transmission of this bacterium has long puzzled researchers. Numerous studies have shown that this microorganism can be detected in dental plaque and saliva of human subjects, suggesting that the oral cavity may be an extra-gastric reservoir of H. pylori and play an important role in both transmission and recurrence. Recent data support this hypothesis and indicate that periodontal therapy may play a role in the management of H. pylori-associated gastric disease.