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World J Gastroenterol. May 14, 2014; 20(18): 5396-5402
Published online May 14, 2014. doi: 10.3748/wjg.v20.i18.5396
Published online May 14, 2014. doi: 10.3748/wjg.v20.i18.5396
Non-platinum-based chemotherapy for treatment of advanced gastric cancer: 5-fluorouracil, taxanes, and irinotecan
Byung Woog Kang, Jong Gwang Kim, Department of Hematology/Oncology, Kyungpook National University Medical Center, Daegu 702-210, South Korea
Oh-Kyoung Kwon, Ho Young Chung, Wansik Yu, Department of Surgery, Kyungpook National University Medical Center, Daegu 702-210, South Korea
Author contributions: Kang BW and Kim JG performed the majority of the study and wrote the manuscript; Kwon OK, Chung HY and Yu W conceived the study and finalized the revision; all authors read and approved the final manuscript.
Supported by Kyungpook National University Research Fund, 2012
Correspondence to: Jong Gwang Kim, MD, PhD, Department of Hematology/Oncology, Kyungpook National University Medical Center, 807 Hogukno, Buk-gu, Daegu 700-712, South Korea. jkk21c@knu.ac.kr
Telephone: +82-53-2003521 Fax: +82-53-2002029
Received: August 6, 2013
Revised: September 4, 2013
Accepted: January 6, 2014
Published online: May 14, 2014
Revised: September 4, 2013
Accepted: January 6, 2014
Published online: May 14, 2014
Core Tip
Core tip: Although platinum-based chemotherapy is adopted widely nowadays in spite of numerous side effects, there is still no standard treatment for palliative chemotherapy of advanced gastric cancer. The current review assessed the efficacy and tolerability of non-platinum-based chemotherapy as first-line palliative treatment in patients with inoperable advanced gastric cancer. The results showed that non-platinum-based chemotherapy including 5-fluorouracil, taxanes, and irinotecan, would seem to be as effective and tolerable as traditional platinum-based chemotherapy.