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©2014 Baishideng Publishing Group Co., Limited. All rights reserved.
World J Gastroenterol. May 14, 2014; 20(18): 5345-5352
Published online May 14, 2014. doi: 10.3748/wjg.v20.i18.5345
Published online May 14, 2014. doi: 10.3748/wjg.v20.i18.5345
Liver transplantation for hepatic tumors: A systematic review
Matteo Ravaioli, Giorgio Ercolani, Flavia Neri, Matteo Cescon, Giacomo Stacchini, Massimo Del Gaudio, Alessandro Cucchetti, Antonio Daniele Pinna, Department of General Surgery and Transplantation, Sant’Orsola-Malpighi Hospital, University of Bologna, 40138 Bologna, Italy
Author contributions: All the authors contributed equally to this work; Ercolani G conceived the review; Ravaioli M, Ercolani G and Neri F wrote the manuscript; Ravaioli M and Neri F performed the bibliographical research; Cescon M, Cucchetti A, Del Gaudio M and Pinna AD revised the manuscript.
Correspondence to: Giorgio Ercolani, PhD, Department of General Surgery and Transplantation, Sant’Orsola-Malpighi Hospital, University of Bologna, Via Massarenti 9, 40138 Bologna, Italy. giorgio.ercolani@aosp.bo.it
Telephone: +39-51-6363105 Fax: +39-51-6364819
Received: October 12, 2013
Revised: December 6, 2013
Accepted: January 8, 2014
Published online: May 14, 2014
Revised: December 6, 2013
Accepted: January 8, 2014
Published online: May 14, 2014
Core Tip
Core tip: This review includes the most relevant outcomes of liver transplantation (LT) for both primary and metastatic tumors. The use of LT for malignancies has been debated because of the recurrence rate caused by the negative impact of immunosuppressive therapy; however, recent studies show that accurate selection of candidates and pre-LT treatments (surgical, loco-regional or chemotherapeutical) may improve recurrence-free survival. We report the recommendations and accepted guidelines for the use of LT for hepatic tumors and the long term results from the most recent literature; our policy for these indications is also reported.