Attempts to enhance the eradication rate of Helicobacter pylori infection

Core Tip

Core tip: There is no uniform and definite therapeutic regimen for the Helicobacter pylori (H. pylori) eradication currently. Increasing rates of antimicrobial resistance present challenges in maintaining optimal eradication rates. Knowledge of local antibiotic resistance and antibiotic consumption pattern is important in selecting a reliable regimen. In addition, adverse effect profiles of therapeutic regimens are important to enhance compliance rates. Bismuth-containing quadruple, sequential, concomitant, and levofloxacin-based triple therapies are replacing the long-standing standard of the triple regimen. Although various novel regimens and additive agents have indicated favorable outcomes, more studies or validations are needed to become a mainstream H. pylori therapy.