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World J Gastroenterol. Apr 28, 2014; 20(16): 4626-4635
Published online Apr 28, 2014. doi: 10.3748/wjg.v20.i16.4626
Published online Apr 28, 2014. doi: 10.3748/wjg.v20.i16.4626
Gastric nNOS reduction accompanied by natriuretic peptides signaling pathway upregulation in diabetic mice
Hong-Li Lu, Xu Huang, Yi-Song Wu, Chun-Mei Zhang, Xiang-Min Meng, Dong-Hai Liu, Wen-Xie Xu, Department of Physiology, Shanghai Jiaotong University School of Medicine, Shanghai 200240, China
Young-chul Kim, Department of Physiology, Chungbuk National University College of Medicine, Chungbuk 361-763, South Korea
Author contributions: Lu HL, Huang X and Wu YS performed the majority of the experiments; Zhang CM, Meng XM and Liu DH performed the intracellular recording; Kim Y was involved in editing the manuscript; Xu WX designed the study and wrote the manuscript.
Supported by The National Natural Science Foundation of China, No. 31071011; No. 31171107; and the Shanghai Natural Science Foundation, No. 13ZR1423100
Correspondence to: Wen-Xie Xu, Professor, Department of Physiology, Shanghai Jiaotong University School of Medicine, 800 Dongchuan Road, 328 Wenxuan Medical Building, Shanghai 200240, China. wenxiexu@sjtu.edu.cn
Telephone: +86-21-34205639 Fax: +86-21-34205639
Received: July 4, 2013
Revised: October 14, 2013
Accepted: November 2, 2013
Published online: April 28, 2014
Revised: October 14, 2013
Accepted: November 2, 2013
Published online: April 28, 2014
Core Tip
Core tip: The results demonstrated that the expressions of neuronal nitric oxide synthase (nNOS) and numbers NOS neurons were significantly downregulated while natriuretic peptides (NPs) and the natriuretic peptide receptor-A, B, C (NPRs) signaling pathway were upregulated. C-type natriuretic peptide, an NPRs agonist, inhibited nNOS expression in cultured gastric fundus tissue. These findings suggested that upregulation of the NPs signaling pathway may be involved in gastric fundus neuropathy caused by diabetes, by decreasing nNOS expression. The results are interesting and may represent a molecular mechanism of diabetic gastroparesis.