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World J Gastroenterol. Apr 28, 2014; 20(16): 4586-4596
Published online Apr 28, 2014. doi: 10.3748/wjg.v20.i16.4586
Inflammation-related factors predicting prognosis of gastric cancer
Wen-Jun Chang, Yan Du, Xin Zhao, Li-Ye Ma, Guang-Wen Cao
Wen-Jun Chang, Yan Du, Guang-Wen Cao, Department of Epidemiology, Second Military Medical University, Shanghai 200433, China
Xin Zhao, Li-Ye Ma, Department of General Surgery, Changhai Hospital, Second Military Medical University, Shanghai 200438, China
Author contributions: Chang WJ, Du Y and Zhao X collected data, drafted the manuscript and contributed equally to this work; Ma LY critically read this paper; Cao GW supervised and revised the manuscript.
Supported by National Natural Science Fund for China No. 81025015, No. 81372671 and No. 91129301
Correspondence to: Guang-Wen Cao, MD, PhD, Professor of Medicine, Chairman, Department of Epidemiology, Second Military Medical University, 800 Xiangyin Rd., Shanghai 200433, China. gcao@smmu.edu.cn
Telephone: +86-21-81871060 Fax: +86-21-81871060
Received: October 29, 2013
Revised: December 24, 2013
Accepted: January 20, 2014
Published online: April 28, 2014
Core Tip

Core tip: The prognosis of gastric cancer (GC) is not satisfactory, and is associated with Helicobacter pylori and/or Epstein-Barr virus infection, as well as host inflammation-related factors. In this article, we summarize the inflammation-related microbial and host factors that are reported to be associated with GC prognosis from different specimens and populations. So far, few simple panels have been clinically used for predicting GC prognosis. It is necessary to integrate different biomarkers with clinicopathological variables for personalized prediction of GC prognosis. The prognostic values of integrated predicators should be validated in large prospective cohorts before clinical application.