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World J Gastroenterol. Apr 7, 2014; 20(13): 3655-3662
Published online Apr 7, 2014. doi: 10.3748/wjg.v20.i13.3655
Published online Apr 7, 2014. doi: 10.3748/wjg.v20.i13.3655
Lack of association between apolipoprotein C3 gene polymorphisms and risk of nonalcoholic fatty liver disease in a Chinese Han population
Tong-Hong Niu, Man Jiang, Medical College of Qingdao University, Qingdao 266021, Shandong Province, China
Tong-Hong Niu, Man Jiang, Yong-Ning Xin, Xiang-Jun Jiang, Zhong-Hua Lin, Shi-Ying Xuan, Department of Gastroenterology, Qingdao Municipal Hospital, Qingdao 266071, Shandong Province, China
Author contributions: Niu TH and Jiang M contributed equally to the work, both drafted and wrote the article; Xin YN, Jiang XJ and Lin ZH revised the paper; and Xuan SY approved the final version.
Supported by National Natural Science Foundation of China, No. 81170337/H0304
Correspondence to: Shi-Ying Xuan, PhD, Professor, Department of Gastroenterology, Qingdao Municipal Hospital, Qingdao 266071, Shandong Province, China. xsy_emuch@126.com
Telephone: +86-532-88905289 Fax: +86-532-88905293
Received: August 22, 2013
Revised: November 17, 2013
Accepted: January 2, 2014
Published online: April 7, 2014
Revised: November 17, 2013
Accepted: January 2, 2014
Published online: April 7, 2014
Core Tip
Core tip: In this study, we determined the relationship between two polymorphisms in apolipoprotein C3 (APOC3) and susceptibility to nonalcoholic fatty liver disease (NAFLD) in a Han population in China. We also examined the influence of APOC3 genotypes on insulin resistance, obesity, fasting TG levels and total antioxidant status. We found that the two polymorphisms of the APOC3 gene are not associated with a risk of NAFLD, or with lipid profiles, IR and oxidative stress in the Chinese Han population.