Filipovic BR, Filipovic BF. Psychiatric comorbidity in the treatment of patients with inflammatory bowel disease. World J Gastroenterol 2014; 20(13): 3552-3563 [PMID: 24707138 DOI: 10.3748/wjg.v20.i13.3552]
Corresponding Author of This Article
Branislav R Filipovic, Professor, Faculty of Medicine, Institute of Anatomy “Niko Miljanic”, 4/2 Dr Subotica Starijeg, 11000 Belgrade, Serbia. filipovic.branislav@gmail.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Topic Highlight
Open-Access Policy of This Article
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World J Gastroenterol. Apr 7, 2014; 20(13): 3552-3563 Published online Apr 7, 2014. doi: 10.3748/wjg.v20.i13.3552
Psychiatric comorbidity in the treatment of patients with inflammatory bowel disease
Branislav R Filipovic, Branka F Filipovic
Branislav R Filipovic, Faculty of Medicine, Institute of Anatomy “Niko Miljanic”, 11000 Belgrade, Serbia
Branislav R Filipovic, Branka F Filipovic, Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia
Branka F Filipovic, Department of Gastroenterohepatology, Clinical and Hospital Center “Bezanijska Kosa”, 11080 Belgrade, Serbia
Author contributions: Both authors contributed to the manuscript design, reference selection, interpretation of the results discussed in the review, and approved the manuscrip.
Correspondence to: Branislav R Filipovic, Professor, Faculty of Medicine, Institute of Anatomy “Niko Miljanic”, 4/2 Dr Subotica Starijeg, 11000 Belgrade, Serbia. filipovic.branislav@gmail.com
Telephone: +381-11-2684259 Fax: +381-11-2684259
Received: September 29, 2013 Revised: January 11, 2014 Accepted: January 20, 2014 Published online: April 7, 2014
Core Tip
Core tip: The involvement of a dysfunction of brain-gut interactions in the pathogenesis of inflammatory bowel disease (IBD) is represented by a dysfunction of the autonomic nervous system, an abnormal hypothalamic-pituitary-adrenal axis and cholinergic anti-inflammatory pathway, a deleterious effect of stress and depression, an abnormal coupling of the prefrontal cortex-amygdaloid complex, and an abnormal relation between the microbiota and the brain as pro-inflammatory factors. New investigations have provided a critical link between forebrain changes and abdominal pain independent of active disease and drug treatment, providing a potential basis for an explanation of the psychological symptoms and brain influence in the pathogenesis of IBD.
