Propensity score analysis demonstrated the prognostic advantage of anatomical liver resection in hepatocellular carcinoma

doi:10.3748/wjg.v20.i12.3335

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Mar 28, 2014 (publication date) through Apr 23, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Mar 28, 2014; 20(12): 3335-3342
Published online Mar 28, 2014. doi: 10.3748/wjg.v20.i12.3335

Propensity score analysis demonstrated the prognostic advantage of anatomical liver resection in hepatocellular carcinoma

Masayuki Ishii, Toru Mizuguchi, Masaki Kawamoto, Makoto Meguro, Shigenori Ota, Toshihiko Nishidate, Kenji Okita, Yasutohsi Kimura, Thomas T Hui, Koichi Hirata

Masayuki Ishii, Toru Mizuguchi, Masaki Kawamoto, Makoto Meguro, Shigenori Ota, Toshihiko Nishidate, Kenji Okita, Koichi Hirata, Yasutoshi Kimura, Department of Surgery, Surgical Oncology and Science, Sapporo Medical University Hospital, Sapporo Medical University, Sapporo 060-8543, Hokkaido, Japan

Thomas T Hui, Department of Surgery, Children’s Hospital and Research Center Oakland, Oakland, CA 94609, United States

Author contributions: Ishii M and Mizuguchi T contributed equally to this work; Meguro M and Hui TT designed the research; Ota S, Nishidate T, Okita K and Kawamoto M performed research; Kimura Y and Hirata K analyzed the data; Ishii M and Mizuguchi T wrote the paper.

Supported by A Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science, and Technology, No. 23591993; a Grant from the Yuasa Memorial Foundation

Correspondence to: Toru Mizuguchi, MD, PhD, Department of Surgery, Surgical Oncology and Science, Sapporo Medical University School of Medicine, S-1, W-16, Chuo-Ku, Sapporo 060-8543, Hokkaido, Japan. tmizu@sapmed.ac.jp

Telephone: +81-11-6112111 Fax: +81-11-6131678

Received: October 17, 2013
Revised: December 25, 2013
Accepted: January 3, 2014
Published online: March 28, 2014

Core Tip

Core tip: The aim of this study was to compare the prognostic advantage of hepatocellular carcinoma (HCC) patients that underwent anatomic liver resection (AR) or non-anatomic liver resection (NAR) using propensity score-matched populations. Consecutive 268 HCC patients were enrolled and 44 patients from each group were matched using logistic multivariate analysis followed by propensity score analysis. The overall survival of the AR group was significantly longer than that of the NAR group after propensity matching. Vascular invasion and the hepatocyte growth factor level were subsequently found to be independent prognostic factors. AR conveys a survival advantage over NAR in specific subpopulations of HCC patients.