Reappraisal of xenobiotic-induced, oxidative stress-mediated cellular injury in chronic pancreatitis: A systematic review

doi:10.3748/wjg.v20.i11.3033

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Mar 21, 2014 (publication date) through Apr 26, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Systematic Review

World J Gastroenterol. Mar 21, 2014; 20(11): 3033-3043
Published online Mar 21, 2014. doi: 10.3748/wjg.v20.i11.3033

Reappraisal of xenobiotic-induced, oxidative stress-mediated cellular injury in chronic pancreatitis: A systematic review

Ajith K Siriwardena

Ajith K Siriwardena, Hepatobiliary Surgery Unit, Manchester Royal Infirmary, Manchester M13 9WL, United Kingdom

Author contributions: Siriwardena AK solely contributed to this paper.

Correspondence to: Ajith K Siriwardena, MD, FRCS, Professor, Hepatobiliary Surgery Unit, Manchester Royal Infirmary, Oxford Road, Manchester M13 9WL, United Kingdom. ajith.siriwardena@cmft.nhs.uk

Telephone: +44-161-2768886 Fax: +44-161-2764530

Received: September 19, 2013
Revised: November 5, 2013
Accepted: December 3, 2013
Published online: March 21, 2014

Core Tip

Core tip: This review systematically appraises the evidence for the key components of the hypothesis of environmental xenobiotic exposure leading to induction of the cytochrome P450 (CYP) system in the pancreatic acinar cell and in turn compromising the free radical quenching pathway in chronic pancreatitis. The central components of the hypothesis of xenobiotic-induced, micronutrient-deficient oxidative-stress mediated cell injury in chronic pancreatitis: xenobiotic exposure causing CYP induction, acinar CYP induction and hepatocyte mediated CYP by-products causing acinar injury by bile reflux do not withstand objective scrutiny.