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World J Gastroenterol. Mar 14, 2014; 20(10): 2533-2541
Published online Mar 14, 2014. doi: 10.3748/wjg.v20.i10.2533
Published online Mar 14, 2014. doi: 10.3748/wjg.v20.i10.2533
Evaluation of renal function in patients with cirrhosis: Where are we now?
Nicolas Rognant, Sandrine Lemoine, Nephrology Department, Hospices Civils de Lyon, France and University Claude Bernard Lyon I, F-69008 Lyon, France
Nicolas Rognant, School of Biochemistry, University of Bristol, University Walk, Medical Sciences Building, Bristol BS8 1TD, United Kingdom
Author contributions: Rognant N and Lemoine S designed the research, performed data analysis and revised the manuscript; Rognant N wrote the manuscript.
Correspondence to: Nicolas Rognant, MD, PhD, School of Biochemistry, University of Bristol, University Walk, Medical Sciences Building, Bristol BS8 1TD, United Kingdom. nicolasrog@hotmail.com
Telephone: +44-758-4357845 Fax: +44-758-4357845
Received: October 29, 2013
Revised: January 3, 2013
Accepted: January 20, 2014
Published online: March 14, 2014
Revised: January 3, 2013
Accepted: January 20, 2014
Published online: March 14, 2014
Core Tip
Core tip: Cirrhotic patient management frequently requires evaluation of renal function. However, these patients present some specific disturbances that affect the serum creatinine value, making its use to estimate glomerular filtration rate unsuitable. To get a more appropriate evaluation of the glomerular filtration rate, other methods are available such as the use of exogenous markers or assaying cystatin C in the blood, which avoid the drawbacks of the serum creatinine. Recently, a convenient new cystatin C based formula was tested and showed correct performance in cirrhotic patients, even in case of liver failure and/or severely decrease renal function.