Field Of Vision
Copyright ©2014 Baishideng Publishing Group Co., Limited. All rights reserved.
World J Gastroenterol. Mar 14, 2014; 20(10): 2429-2432
Published online Mar 14, 2014. doi: 10.3748/wjg.v20.i10.2429
Intratumoral functional heterogeneity and chemotherapy
Ferenc Sipos, Miklós Constantinovits, Györgyi Műzes
Ferenc Sipos, Miklós Constantinovits, Györgyi Műzes, 2nd Department of Internal Medicine, Semmelweis University, 1088 Budapest, Hungary
Author contributions: Sipos F, Constantinovits M and Műzes G contributed to writing, editing and revising of this paper.
Correspondence to: Györgyi Műzes, MD, PhD, 2nd Department of Internal Medicine, Semmelweis University, Szentkirályi str. 46, 1088 Budapest, Hungary. muzes.gyorgyi@med.semmelweis-univ.hu
Telephone: +36-12-660926  Fax: +36-12-660816
Received: November 1, 2013
Revised: December 19, 2013
Accepted: January 14, 2014
Published online: March 14, 2014
Core Tip

Core tip: Beyond genetic diversity, a complex level of nongenetic mechanisms exists and drives the intratumoral inherent functional heterogeneity of tumor cells. Recent data suggest that changes in clonal dynamics of colorectal cancer cells can lead to drug resistance and tumor reappearance.