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World J Gastroenterol. Jan 7, 2014; 20(1): 193-203
Published online Jan 7, 2014. doi: 10.3748/wjg.v20.i1.193
Published online Jan 7, 2014. doi: 10.3748/wjg.v20.i1.193
Apoptotic pathway induced by diallyl trisulfide in pancreatic cancer cells
Hong-Bing Ma, Shan Huang, Xiao-Ran Yin, Yang Zhang, Department of Radiotherapy of Tumor Hospital, the Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710004, Shaanxi Province, China
Zheng-Li Di, Department of Neurology, Xi’an Center Hospital, Xi’an 710004, Shaanxi Province, China
Author contributions: Ma HB and Di ZL performed the majority of experiments; Yin XR and Zhang Y provided vital reagents and analytical tools and revised the manuscript; Ma HB and Huang S designed the study and wrote the manuscript.
Supported by Fund for Science and Technology Program of Shaanxi Province, China, No. 2010K01-141
Correspondence to: Hong-Bing Ma, PhD, Department of Radiotherapy of Tumor Hospital, the Second Hospital of Xian Jiaotong University, No. 157, Xiwulu, Xi’an 710004, Shaanxi Province, China. mhbxian@126.com
Telephone: +86-29-87679789 Fax: +86-29-87679789
Received: June 7, 2013
Revised: October 17, 2013
Accepted: November 2, 2013
Published online: January 7, 2014
Revised: October 17, 2013
Accepted: November 2, 2013
Published online: January 7, 2014
Core Tip
Core tip: We investigated the effect of diallyl trisulfide (DATS), a promising cancer chemopreventive constituent of processed garlic, in human pancreatic cancer cells (Capan-2) and non-tumorigenic pancreatic ductal epithelial cells (H6C7), and explored the possible mechanism involved. We found that DATS can induce apoptosis in both cell lines. We also investigated the role of p53, Bcl-2 and the cell cycle in apoptosis of Capan-2 and H6C7 cells.