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World J Gastroenterol. Jan 7, 2014; 20(1): 163-174
Published online Jan 7, 2014. doi: 10.3748/wjg.v20.i1.163
Published online Jan 7, 2014. doi: 10.3748/wjg.v20.i1.163
Serum and urine metabolomic fingerprinting in diagnostics of inflammatory bowel diseases
Tomasz Dawiskiba, Jan Skóra, Piotr Barć, Krzysztof Korta, Kornel Pormańczuk, Przemyslaw Szyber, Department of Vascular, General and Transplantation Surgery, Wroclaw Medical University, 50-556 Wroclaw, Poland
Stanisław Deja, Faculty of Chemistry, Opole University, 45-040 Opole, Poland
Agata Mulak, Department of Gastroenterology and Hepatology, Wroclaw Medical University, 50-556 Wroclaw, Poland
Adam Ząbek, Ewa Jawień, Piotr Młynarz, Bioorganic Chemistry Group, Department of Chemistry, Wroclaw University of Technology, 50-370 Wroclaw, Poland
Dorota Pawełka, Waldemar Balcerzak, Krzysztof Kaliszewski, First Department and Clinic of General, Gastroenterological and Endocrinological Surgery, Wroclaw Medical University, 50-369 Wrocław, Poland
Mirosław Banasik, Department and Clinic of Nephrology and Transplantation Medicine, Wroclaw Medical University, 50-556 Wroclaw, Poland
Agnieszka Mastalerz-Migas, Department of Family Medicine, Wroclaw Medical University, 51-141 Wroclaw, Poland
Adam Litarski, Department of Urology, 4th Military Clinical Hospital, 50-981 Wroclaw, Poland
Author contributions: Dawiskiba T and Młynarz P designed the research; Dawiskiba T supervised the research; Mulak A coordinated the collection of human material; Mulak A, Pawełka D, Balcerzak W, Kaliszewski K, Mastalerz-Migas A, Skóra J, Barć P, Korta K, Pormańczuk K and Szyber P were involved in the collection of human material from inflammatory bowel diseases patients and contributed to database construction; Litarski A collected human material from healthy control subjects; Deja S, Ząbek A, Jawień E and Młynarz P performed the major part of the experimental work and performed the chemometrics and the statistical analysis; Dawiskiba T, Deja S, Ząbek A and Młynarz P analyzed the data; Dawiskiba T and Banasik M performed the extensive literature search; Dawiskiba T, Deja S, Mulak A, Ząbek A and Młynarz P prepared the manuscript; Mulak A and Młynarz P revised the manuscript critically.
Supported by Wroclaw Medical University Research Program, Grant Number 15/Pbmn
Correspondence to: Tomasz Dawiskiba, MD, PhD, Department of Vascular, General and Transplantation Surgery, Wroclaw Medical University, 213 Borowska Street, 50-556 Wroclaw, Poland. tomasz.dawiskiba@umed.wroc.pl
Telephone: +48-71-7332002 Fax: +48-71-7332009
Received: October 24, 2013
Revised: November 21, 2013
Accepted: December 5, 2013
Published online: January 7, 2014
Revised: November 21, 2013
Accepted: December 5, 2013
Published online: January 7, 2014
Core Tip
Core tip: This study demonstrates that proton nuclear magnetic resonance -based metabolic fingerprinting of human serum and urine combined with multivariate data analysis could be a useful tool for differentiation between the active and remission phase of the disease that is of great importance in inflammatory bowel diseases (IBD) monitoring. At the same time, the results indicate that this diagnostic method has rather a weak potential in the differential diagnosis of IBD.