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World J Gastroenterol. Dec 28, 2013; 19(48): 9461-9471
Published online Dec 28, 2013. doi: 10.3748/wjg.v19.i48.9461
Published online Dec 28, 2013. doi: 10.3748/wjg.v19.i48.9461
TNF-α-308 polymorphism and risk of digestive system cancers: A meta-analysis
Xu-Feng Guo, Jun Wang, Shi-Jie Yu, Jia Song, Meng-Yao Ji, Zhuo Cao, Ji-Xiang Zhang, Jing Wang, Wei-Guo Dong, Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei Province, China
Author contributions: Guo XF and Wang J contributed equally to this work. Guo XF wrote the manuscript; Wang J conducted the analysis of pooled data; Yu SJ, Song J, Ji MY, Cao Z, Zhang JX and Wang J collected the literature; Dong WG revised the manuscript.
Correspondence to: Dr. Wei-Guo Dong, Department of Gastroenterology, Renmin Hospital of Wuhan University, 238 Jiefang Road, Wuhan 430060, Hubei Province, China. dwg@whu.edu.cn
Telephone: +86-27-88041911 Fax: +86-27-88042292
Received: September 2, 2013
Revised: October 11, 2013
Accepted: November 2, 2013
Published online: December 28, 2013
Revised: October 11, 2013
Accepted: November 2, 2013
Published online: December 28, 2013
Core Tip
Core tip: Genetic polymorphisms contribute to the risk of human malignant tumours. Many studies have reported the relationship between the tumour necrosis factor alpha-308 (TNF-α-308) gene polymorphism and risk of digestive system cancers. However, the results of these studies are inconsistent and contradictory. In this meta-analysis, our results suggest that the TNF-α-308 polymorphism is significantly associated with the risk of gastric and hepatocellular carcinomas in the Asian population (dominant model: 95%CI: 1.02-1.34, P < 0.05 and 95%CI: 1.20-2.54, P < 0.05, respectively). This finding indicates that certain polymorphisms and mutations at TNF-α-308 may increase susceptibility to digestive system cancers.