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World J Gastroenterol. Dec 28, 2013; 19(48): 9439-9446
Published online Dec 28, 2013. doi: 10.3748/wjg.v19.i48.9439
Published online Dec 28, 2013. doi: 10.3748/wjg.v19.i48.9439
Oxidative stress induces gastric submucosal arteriolar dysfunction in the elderly
Lei Liu, Jie Cui, Wei-Li Qiao, Hong Sun, Chang-Dong Yan, Department of Physiology, Xuzhou Medical College, Xuzhou 221004, Jiangsu Province, China
Yan Liu, Jiangsu Provincial Key Laboratory of Anesthesiology, Xuzhou Medical College, Xuzhou 221004, Jiangsu Province, China
Hong Liu, Department of Pathology, Xuzhou Medical College, Xuzhou 221004, Jiangsu Province, China
Yan-Bing Liu, Department of Anesthesiology, Second Affiliated Hospital of Xuzhou Medical College, Xuzhou 221000, Jiangsu Province, China
Author contributions: Yan CD and Sun H designed the research; Liu L, Liu H, Liu Y, Cui J, Liu YB, Qiao WL performed the research; Liu L, Liu Y and Yan CD analyzed the data and wrote the paper.
Supported by The Natural Science Foundation of Jiangsu Province, China, No. BK2009088; and the Natural Science Fund for Colleges and Universities in Jiangsu Province, No. 10KJB310015
Correspondence to: Chang-Dong Yan, MD, Department of Physiology, Xuzhou Medical College, No. 209, Tongshan Road, Xuzhou 221004, Jiangsu Province, China. yancd55@163.com
Telephone: +86-516-83262105 Fax: +86-516-83262014
Received: September 26, 2013
Revised: November 5, 2013
Accepted: November 12, 2013
Published online: December 28, 2013
Revised: November 5, 2013
Accepted: November 12, 2013
Published online: December 28, 2013
Core Tip
Core tip: Aging is usually accompanied by a high risk of gastric disease. It is currently thought that adequate mucosal blood flow plays an important role in maintaining mucosal integrity. This study showed that oxidative stress induces gastric submucosal vascular structure dysfunction during the aging process. Vascular aging of gastric mucosa may lead to blood supply insufficiency, and thus increase the incidence of gastric diseases.