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World J Gastroenterol. Dec 28, 2013; 19(48): 9231-9239
Published online Dec 28, 2013. doi: 10.3748/wjg.v19.i48.9231
Published online Dec 28, 2013. doi: 10.3748/wjg.v19.i48.9231
Sleep, immunity and inflammation in gastrointestinal disorders
Tauseef Ali, Inflammatory Bowel Disease Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, United States
James Choe, William C Orr, Department of Medicine, University of Oklahoma Health Science Center, Oklahoma City, OK 73104, United States
Ahmed Awab, Department of Medicine, Section of Pulmonary and Critical Care, Oklahoma City, OK 73104, United States
Theodore L Wagener, Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, United States
William C Orr, Lynn Health Science Institute, Oklahoma City, OK 73112, United States
Author contributions: The idea was proposed by Ali T; Ali T and Choe J drafted the initial manuscript; Awab A, Wagener TL and Orr WC reviewed and edited the draft; all authors approved the final manuscript before submission.
Correspondence to: Tauseef Ali, MD, Inflammatory Bowel Disease Center, University of Oklahoma Health Sciences Center, 920 SL Young Blvd. WP 1345, Oklahoma City, OK 73104, United States. tauseef-ali@ouhsc.edu
Telephone: +1-405-2715428 Fax: +1-405-2715803
Received: July 21, 2013
Revised: September 11, 2013
Accepted: September 29, 2013
Published online: December 28, 2013
Revised: September 11, 2013
Accepted: September 29, 2013
Published online: December 28, 2013
Core Tip
Core tip: Sleep disorders have become a global issue, and discovering their causes and consequences are the focus of many research endeavors. Recent research suggests that individuals with sleep abnormalities are at greater risk of all-cause mortality and serious adverse health and economic consequences. Several studies support the associations among sleep, immune function and inflammation. We review the current research linking sleep, immune function, and gastrointestinal diseases and discuss the interdependent relationship between sleep, overall immune function with emphasis on inflammatory bowel disease, irritable bowel syndrome, gastro-esophageal reflux and colorectal cancer.