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World J Gastroenterol. Dec 7, 2013; 19(45): 8366-8372
Published online Dec 7, 2013. doi: 10.3748/wjg.v19.i45.8366
Published online Dec 7, 2013. doi: 10.3748/wjg.v19.i45.8366
Application of quantitative estimates of fecal hemoglobin concentration for risk prediction of colorectal neoplasia
Chao-Sheng Liao, Yu-Min Lin, Hung-Chuen Chang, Lee-Won Chong, Chun-Hao Chen, Kuo-Ching Yang, Division of Gastroenterology, Department of Internal Medicine, Shin Kong Wu Ho-Su Memorial Hospital, Taipei 111, Taiwan
Yu-Hung Chen, Department of Family Medicine, Shin Kong Wu Ho-Su Memorial Hospital, Taipei 111, Taiwan
Yueh-Shih Lin, Health Management Center, Shin Kong Wu Ho-Su Memorial Hospital, Taipei 111, Taiwan
Chao-Sheng Liao, Yu-Min Lin, School of Medicine, Fu Jen Catholic University, New Taipei City 24205, Taiwan
Chia-Hui Shih, Chang Gung Institute of Technology, School of Nursing, Tao-Yuan 333, Taiwan
Author contributions: Liao CS and Lin YM designed the study and wrote the manuscript; Chang HC, Chen YH, Chong LW and Chen CH acquired and collected the data; Lin YS and Shih CH analyzed the data; Yang KC revised the manuscript; all authors have read and approved the final version to be published.
Correspondence to: Yu-Min Lin, MD, Division of Gastroenterology, Department of Internal Medicine, Shin Kong Wu Ho-Su Memorial Hospital, No. 95, Wen Chang Road, Shih Lin District, Taipei 111, Taiwan. M001063@ms.skh.org.tw
Telephone: +886-2-28332211-2031 Fax: +886-2-28389335
Received: June 30, 2013
Revised: August 15, 2013
Accepted: August 28, 2013
Published online: December 7, 2013
Revised: August 15, 2013
Accepted: August 28, 2013
Published online: December 7, 2013
Core Tip
Core tip: The fecal immunochemical test (FIT) for hemoglobin is specific for detecting colorectal lesions. With adjustment for age and gender of 17 881 attendees at a colorectal cancer screening program in a single hospital, we demonstrated that higher FIT concentrations were associated with more advanced histological grades (β = 0.088, P < 0.01). A significant log-linear relationship was found between the FIT concentration and positive predictive value of the FIT for predicting colorectal tumors (R2 > 0.95, P < 0.001). Risk stratification for colorectal neoplasia based on individual FIT concentration may help to improve the performance of screening programs.