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World J Gastroenterol. Dec 7, 2013; 19(45): 8292-8300
Published online Dec 7, 2013. doi: 10.3748/wjg.v19.i45.8292
Published online Dec 7, 2013. doi: 10.3748/wjg.v19.i45.8292
Cooperative inhibitory effect of sinomenine combined with 5-fluorouracil on esophageal carcinoma
Jing Wang, Zi-Rong Yang, Wei-Guo Dong, Ji-Xiang Zhang, Xu-Feng Guo, Jia Song, Shi Qiu, Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei Province, China
Author contributions: Wang J, Yang ZR, Dong WG, Zhang JX, Guo XF, Song J and Qiu S designed the research; Wang J, Yang ZR, Zhang JX and Guo XF performed the research; Wang J, Yang ZR, Song J and Qiu S analyzed the data; Wang J and Yang ZR wrote the paper.
Correspondence to: Wei-Guo Dong, MD, Department of Gastroenterology, Renmin Hospital of Wuhan University, No. 99 Zhang Zhi-dong Road, Wuhan 430060, Hubei Province, China. dwg@whu.edu.cn
Telephone: +86-27-88041911 Fax: +86-27-88042992
Received: August 27, 2013
Revised: October 4, 2013
Accepted: October 13, 2013
Published online: December 7, 2013
Revised: October 4, 2013
Accepted: October 13, 2013
Published online: December 7, 2013
Core Tip
Core tip: The cooperative inhibitory effects of sinomenine (SIN) and 5-fluorouracil (5-FU) on esophageal carcinoma in vitro and in vivo were investigated. SIN and 5-FU alone or in combination significantly inhibited the proliferation and induced apoptosis of esophageal carcinoma cells in a dose-dependent manner. The essential mechanism underlying SIN and 5-FU-induced apoptosis, as investigated by Western blotting, involved the mitochondrial pathway. No obvious side effects were observed in the liver and kidneys of nude mice. These results indicated that the combined effects of SIN and 5-FU on esophageal carcinoma were superior to the effects of the individual compounds, without an increase in side effects.