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World J Gastroenterol. Nov 28, 2013; 19(44): 8099-8107
Published online Nov 28, 2013. doi: 10.3748/wjg.v19.i44.8099
Published online Nov 28, 2013. doi: 10.3748/wjg.v19.i44.8099
Decreased histone H2B monoubiquitination in malignant gastric carcinoma
Zi-Jing Wang, Jiang-Yan Lou, Jie Chen, Cong Liu, Lian-Di Guo, Key Laboratory of Obstetric, Gynecologic and Pediatric Diseases and Birth Defects of the Ministry of Education, Department of Gynecology, West China Second University Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
Zi-Jing Wang, Jing-Lin Yang, Yi-Ping Wang, Department of Digestive Medicine, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
Author contributions: Wang ZJ, Liu C designed the study and wrote the manuscript; Wang ZJ performed the experiments; Yang JL, Wang YP summarized the immunostaining results and analyzed the data; Lou JY, Chen J provided vital reagents and clinical samples; Guo LD wrote the discussion and revised the entire article for intellectual content; all authors have read and approved the final version of the manuscript.
Supported by The Ministry of Science and Technology of China, No. 2011CB966200 and 2013CB911000; the National Natural Science Foundation of China, No. 30970950, 81071362, and 31171319; the Program for Changjiang Scholars and Innovative Research Team in University of Ministry of Education of China, the Department of Science and Technology of Sichuan Province, No. 2011SZ0002 and 2012JQ0005; and the Bureau of Science and Technology of Chengdu, No. 11PPYB072SF
Correspondence to: Cong Liu, PhD, Professor, Key Laboratory of Obstetric, Gynecologic and Pediatric Diseases and Birth Defects of the Ministry of Education, Department of Gynecology, West China Second University Hospital, Sichuan University, No.20, Section 3, Ren Min Nan Lu Road, Chengdu 610041, Sichuan Province, China. congliu@scu.edu.cn
Telephone: +86-28-85501727 Fax: +86-28-85501727
Received: August 5, 2013
Revised: September 23, 2013
Accepted: October 19, 2013
Published online: November 28, 2013
Revised: September 23, 2013
Accepted: October 19, 2013
Published online: November 28, 2013
Core Tip
Core tip: The abundant H2B monoubiquination (uH2B) modification detected by immunohistochemistry (IHC) in normal human gastric epithelium is decreased in malignant gastric cancer specimens, and the decreasing trend is correlated with decreased tumor differentiation, Lauren’s classification intestinal-type, presence of lymph node metastasis, and TNM stage. Positive uH2B staining is associated with higher 5-year survival. Multivariate analysis identified uH2B modification level as an independent prognostic factor for gastric cancer-specific survival. Collectively, these findings indicate the clinical significance of IHC-detected uH2B differential staining patterns as a potential prognostic biomarker in early stage gastric cancer.