Brief Article
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World J Gastroenterol. Nov 28, 2013; 19(44): 8065-8070
Published online Nov 28, 2013. doi: 10.3748/wjg.v19.i44.8065
Effects of disease severity and necrosis on pancreatic dysfunction after acute pancreatitis
Gokhan Garip, Emre Sarandöl, Ekrem Kaya
Gokhan Garip, Ekrem Kaya, Department of Surgery, Uludag University School of Medicine, 16059 Gorukle-Bursa, Turkey
Emre Sarandöl, Department of Biochemistry, Uludag University School of Medicine, 16059 Gorukle-Bursa, Turkey
Author contributions: Garip G and Kaya E contributed equally to this work and wrote the paper; Sarandöl E analyzed the blood samples and laboratory data.
Supported by Uludag University Resources Committee
Correspondence to: Ekrem Kaya, MD, Department of Surgery, Uludag University School of Medicine, HPB Unit, 16059 Gorukle-Bursa, Turkey. ekremkaya@uludag.edu.tr
Telephone: +90-224-4428398 Fax: +90-224-4428398
Received: March 28, 2013
Revised: August 21, 2013
Accepted: September 16, 2013
Published online: November 28, 2013
Core Tip

Core tip: The aim of this study was to evaluate the effects of disease severity and necrosis on organ dysfunctions in acute pancreatitis (AP). Exocrine and endocrne dysfunctions were investigated according to disease severity and necrosis ratio after acute pancreatitis. Exocrine dysfunction was identified in 13.7% of the patients [17.9% were in severe AP (SAP), 11.4% were in mild AP (MAP) and 34.7% of all of the patients had endocrine dysfunction (56.4% in SAP and 23.2% in MAP)]. Forty percent of the patients who had undergone necrosectomy developed exocrine dysfunction. Endocrine dysfunction was more significant in patients with SAP and NAP. All of the patients in the necrosectomy group had endocrine dysfunction. Patients with SAP, NAP, pancreatic head necrosis and necrosectomy should be followed for pancreatic functions.