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World J Gastroenterol. Nov 28, 2013; 19(44): 8034-8041
Published online Nov 28, 2013. doi: 10.3748/wjg.v19.i44.8034
Published online Nov 28, 2013. doi: 10.3748/wjg.v19.i44.8034
Predictors of Clostridium difficile infection severity in patients hospitalised in medical intensive care
Nagham Khanafer, Philippe Vanhems, Laboratory of Epidemiology and Public Health, CNRS UMR 5558, University of Lyon, 69 373 Lyon, France
Nagham Khanafer, Abdoulaye Touré, Philippe Vanhems, Epidemiology and Infection Control Unit, Edouard Herriot Hospital, Hospices Civils of Lyon, 69437 Lyon, France
Cécile Chambrier, INSERM Unit 1060, INRA 1235, University of Lyon, 69921 Oullins, France
Abdoulaye Touré, Cécile Chambrier, Clinical Nutrition Intensive Care Unit, Croix Rousse Hospital, Hospices Civils of Lyon, 69317 Lyon, France
Martin Cour, Laurent Argaud, Medical Intensive Care Unit, Edouard Herriot Hospital, Hospices Civils of Lyon, 69437 Lyon, France
Marie-Elisabeth Reverdy, Microbiology Laboratory, Hospices Civils of Lyon, 69677 Bron, France
Author contributions: Khanafer N contributed to the conception, data acquisition, analysis and interpretation, drafting of manuscript and final approval; Touré A actively participated in the conception, data acquisition, analysis and interpretation, revising and final approval of the manuscript; Chambrier C, Argaud L and Cour M partook in the interpretation, revising and final approval of the manuscript; Reverdy ME performed the microbiological tests; Vanhems P was involved in the conception, interpretation, revising and final approval of the manuscript.
Supported by A grant for her PhD from Sanofi Pasteur, France, to Khanafer N
Correspondence to: Nagham Khanafer, PharmD, MPH, PhD, Epidemiology and Infection Control Unit, Edouard Herriot Hospital, Hospices Civils of Lyon, 69437 Lyon, Cedex 03, France. nagham.khanafer@chu-lyon.fr
Telephone: +33-4-27858063 Fax: +33-4-72110726
Received: April 30, 2013
Revised: July 21, 2013
Accepted: July 9, 2013
Published online: November 28, 2013
Revised: July 21, 2013
Accepted: July 9, 2013
Published online: November 28, 2013
Core Tip
Core tip: We reported that male gender, rising serum C-reactive protein level, and previous exposure to fluoroquinolones were independently associated with severe Clostridium difficile infection (CDI) in medical intensive care unit. This could help in the development of a quantitative severity score that could fuel comparative effectiveness studies and prospective trials of CDI therapy in critically-ill patients.