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World J Gastroenterol. Nov 21, 2013; 19(43): 7569-7576
Published online Nov 21, 2013. doi: 10.3748/wjg.v19.i43.7569
Autoantibodies and an immune-based rat model of inflammatory bowel disease
Hadi Esmaily, Yara Sanei, Mohammad Abdollahi
Hadi Esmaily, Faculty of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran 1985717443, Iran
Yara Sanei, Mohammad Abdollahi, Faculty of Pharmacy, Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran 1417614411, Iran
Author contributions: Esmaily H, Sanei Y and Abdollahi M contributed equally to this work.
Correspondence to: Mohammad Abdollahi, Professor, Faculty of Pharmacy, Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Poursina Street, Tehran 1417614411, Iran. mohammad@tums.ac.ir
Telephone: +98-21-66959104 Fax: +98-21-66959104
Received: June 29, 2013
Revised: September 28, 2013
Accepted: October 13, 2013
Published online: November 21, 2013
Core Tip

Core tip: We present a new hypothesis to distinguish the complex links between genetic susceptibility, barrier dysfunction, commensal and pathologic microbial factors and inflammatory response (especially autoantibodies) in the pathogenesis of inflammatory bowel disease (IBD). In our hypothesis, we suggest that prior activation of adaptive immunity against microbial flora antigens could initiate an IBD-like chronic inflammation if something like ethanol disturbs barrier function. If this hypothesis is supported with further experiments, it would illustrate unknown aspects of IBD pathogenesis. On this basis, we have developed a new immune-based model of IBD with the presence of antibodies against enteric bacterial antigens.