Published online Oct 28, 2013. doi: 10.3748/wjg.v19.i40.6911
Revised: August 24, 2013
Accepted: September 3, 2013
Published online: October 28, 2013
Core tip: For many decades, researchers have carried out studies on the treatment of nonalcoholic fatty liver disease (NAFLD). However, no firm conclusions have been made regarding the efficacy of various treatments for NAFLD. Here we conducted a meta-analysis of the pooled data from randomized controlled trials to assess the efficacy of probiotic therapies and showed that probiotic therapy signiﬁcantly decreased alanine aminotransferase, aspartate transaminase, total-cholesterol, high density lipoprotein, tumor necrosis factor-α and homeostasis model assessment of insulin resistance. Thus, probiotics may help to improve liver function, fat metabolism and insulin resistance in NAFLD patients.