Brief Article
Copyright ©2013 Baishideng Publishing Group Co., Limited. All rights reserved.
World J Gastroenterol. Sep 28, 2013; 19(36): 6020-6025
Published online Sep 28, 2013. doi: 10.3748/wjg.v19.i36.6020
Disparities of conjugating protective enzyme activities in the colon of patients with adenomas and carcinomas
Harald P Hoensch, Hennie MJ Roelofs, Lutz Edler, Wilhelm Kirch, Wilbert HM Peters
Harald P Hoensch, Internal Medicine, Marien Hospital, D-64285 Darmstadt, Germany
Hennie MJ Roelofs, Wilbert HM Peters, Department of Gastroenterology, Radboud University Nijmegen Medical Center, 6525 GA Nijmegen, The Netherlands
Lutz Edler, Division of Biostatistics, German Cancer Research Center, D-69120 Heidelberg, Germany
Wilhelm Kirch, Department of Clinical Pharmacology, Technical University of Dresden, D-01307 Dresden, Germany
Author contributions: Hoensch HP is responsible for the study design, analysis and writing of the manuscript; Peters WHM and Roelofs HMJ performed the enzyme assays; Edler L analysed the data; Kirch W acts as guarantor for this article.
Supported by The Technical University of Dresden/Germany
Correspondence to: Harald P Hoensch, Professor, Internal Medicine, Marien Hospital, Martinspfad 72, Darmstadt D-64285, Germany. h.p.hoensch@t-online.de
Telephone: +49-6152-56768 Fax: +49-6152-56742
Received: April 9, 2013
Revised: June 26, 2013
Accepted: July 30, 2013
Published online: September 28, 2013
Core Tip

Core tip: Protective enzymes can conjugate carcinogenic chemicals. The functional capacity of these enzymes is diminished in patients with colorectal cancer and in some patients with colon adenomas.