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World J Gastroenterol. Sep 21, 2013; 19(35): 5855-5862
Published online Sep 21, 2013. doi: 10.3748/wjg.v19.i35.5855
Published online Sep 21, 2013. doi: 10.3748/wjg.v19.i35.5855
Role of Salmonella enterica exposure in Chilean Crohn's disease patients
Manuel Alvarez-Lobos, Patricio Ibañez, Carlos Quintana, CAREI Group (Active Cohort Registry of Inflammatory Bowel Disease), Department of Gastroenterology, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago 6510260, Chile
Daniela P Pizarro, Christian E Palavecino, Abner Espinoza, Valentina P Sebastián, Alexis M Kalergis, Susan M Bueno, Millennium Institute on Immunology and Immunotherapy, Departamento de Genética Molecular y Microbiología, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago 8331150, Chile
Juan C Alvarado, School of Medicine, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago 6510260, Chile
Orlando Díaz, Department of Respiratory Diseases, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago 6510260, Chile
Author contributions: Alvarez-Lobos M and Pizarro DP contributed equally to this work; Alvarez-Lobos M, Kalergis AM and Bueno SM designed the research; Alvarez-Lobos M, Pizarro DP, Palavecino CE, Espinoza A, Sebastian VP, Alvarado JC, Ibañez P, Quintana C, Díaz O and Bueno SM performed the research; Díaz O contributed new reagents and analytic tools; Alvarez-Lobos M, Pizarro DP, Alvarado JC, Ibañez P, Quintana C, Kalergis AM and Bueno SM analyzed the data; Alvarez-Lobos M, Pizarro DP, Ibañez P, Kalergis AM and Bueno SM wrote the paper and provided financial support for this work.
Supported by The Fondo Nacional de Ciencia y Tecnología de Chile, No. 1100971; and the Millennium Institute on Immunology and Immunotherapy, No. P09/016F
Correspondence to: Susan M Bueno, PhD, Millennium Institute on Immunology and Immunotherapy, Department of Molecular Genetics and Microbiology, School of Biological Sciences, Pontificia Universidad Católica de Chile, Avenida Libertador Bernardo OHiggins 340, Santiago 8331150, Chile. sbueno@bio.puc.cl
Telephone: +56-2-26862842 Fax: +56-2-26862185
Received: February 4, 2013
Revised: June 3, 2013
Accepted: July 18, 2013
Published online: September 21, 2013
Revised: June 3, 2013
Accepted: July 18, 2013
Published online: September 21, 2013
Core Tip
Core tip: The role and clinical implications of Salmonella enterica (SE) in Crohn’s disease (CD) are controversial and currently unknown. We evaluated the role of exposure to SE in a cohort of Chilean patients suffering from CD. Although our study showed no association between SE exposure and CD, we observed a positive correlation between SE exposure and cigarette smoking in CD patients, but not with disease severity. These data provide evidence that more precisely defines the real role of Salmonella infection, an important environmental factor in CD.