Koizumi S, Kamisawa T, Kuruma S, Tabata T, Chiba K, Iwasaki S, Endo Y, Kuwata G, Koizumi K, Shimosegawa T, Okazaki K, Chiba T. Immunoglobulin G4-related gastrointestinal diseases, are they immunoglobulin G4-related diseases? World J Gastroenterol 2013; 19(35): 5769-5774 [PMID: 24124321 DOI: 10.3748/wjg.v19.i35.5769]
Corresponding Author of This Article
Terumi Kamisawa, MD, PhD, Department of Internal Medicine, Tokyo Metropolitan Komagome Hospital, 3-18-22 Honkomagome, Bunkyo-ku, Tokyo 113-8677, Japan. kamisawa@cick.jp
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Editorial
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Satomi Koizumi, Terumi Kamisawa, Sawako Kuruma, Taku Tabata, Kazuro Chiba, Susumu Iwasaki, Yuka Endo, Go Kuwata, Koichi Koizumi, Department of Internal Medicine, Tokyo Metropolitan Komagome Hospital, Tokyo 113-8677, Japan
Tooru Shimosegawa, Division of Gastroenterology, Tohoku University, Sendai 980-8574, Japan
Kazuichi Okazaki, Department of Gastroenterology and Hepatology, Kansai Medical University, Hirakata 573-1191, Japan
Tsutomu Chiba, Department of Gastroenterology, Kyoto University, Kyoto 606-8507, Japan
Author contributions: Koizumi S and Kamisawa T contributed equally to this work, analyzed the data and wrote the manuscript; Kuruma S, Tabata T, Chiba K, Iwasaki S, Endo Y, Kuwata G and Koizumi K searched the literature; Shimosegawa T, Okazaki K and Chiba T evaluated and edited the manuscript.
Supported by Health and Labour Sciences Research Grants for Research on Intractable diseases (Research on IgG4-related disease) from Ministry of Health, Labour and Welfare of Japan
Correspondence to: Terumi Kamisawa, MD, PhD, Department of Internal Medicine, Tokyo Metropolitan Komagome Hospital, 3-18-22 Honkomagome, Bunkyo-ku, Tokyo 113-8677, Japan. kamisawa@cick.jp
Telephone: +81-3-38232101 Fax: +81-3-38241552
Received: April 11, 2013 Revised: June 15, 2013 Accepted: July 18, 2013 Published online: September 21, 2013
Core Tip
Core tip: Although the concept of immunoglobulin G4 (IgG4)-related gastrointestinal disease remains unclear, there appear to be two types of IgG4-related gastrointestinal disease. One is a gastrointestinal lesion showing marked thickening of the wall of the esophagus and stomach, consisting of dense fibrosis with abundant infiltration of IgG4-positive plasma cells, which usually show submucosal spreading. The other is an IgG4-related pseudotumor occurring in gastrointestinal regions such as the stomach, colon, and major duodenal papilla, showing polypoid or mass-like lesions. It is of utmost importance to rule out malignancy. To avoid unnecessary resection, IgG4-related gastrointestinal diseases should be considered in the differential diagnosis.
