Shan GD, Hu FL, Yang M, Chen HT, Chen WG, Wang YG, Chen LH, Li YM, Xu GQ. Clonal immunoglobulin heavy chain and T-cell receptor γ gene rearrangements in primary gastric lymphoma. World J Gastroenterol 2013; 19(34): 5727-5731 [PMID: 24039368 DOI: 10.3748/wjg.v19.i34.5727]
Corresponding Author of This Article
Dr. Guo-Qiang Xu, Department of Gastroenterology, the First Affiliated Hospital, School of Medicine, Zhejiang University, Qing Chun Road 79, Hangzhou 321000, Zhejiang Province, China. xgqhangzhou@163.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Brief Article
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Guo-Dong Shan, Feng-Ling Hu, Ming Yang, Hong-Tan Chen, Wen-Guo Chen, Yun-Gui Wang, Li-Hua Chen, You-Ming Li, Guo-Qiang Xu, Department of Gastroenterology, the First Affiliate Hospital, School of Medicine, Zhejiang University, Hangzhou 321000, Zhejiang Province, China
Author contributions: Xu GQ and Li YM designed the research; Shan GD, Hu FL, Chen HT, Wang YG and Chen LH performed the research; Yang M contributed new reagents and analytic tools; Chen WG analyzed the data; Shan GD wrote the paper.
Supported by The Scientific Research Foundation of the Ministry of Health, China, the Medical and Health Science Foundation, Zhejiang Province, China, No. WKJ-2009-2-021
Correspondence to: Dr. Guo-Qiang Xu, Department of Gastroenterology, the First Affiliated Hospital, School of Medicine, Zhejiang University, Qing Chun Road 79, Hangzhou 321000, Zhejiang Province, China. xgqhangzhou@163.com
Telephone: +86-571-87236718 Fax: +86-571-87236718
Received: May 18, 2013 Revised: July 24, 2013 Accepted: August 4, 2013 Published online: September 14, 2013
Core Tip
Core tip: In 2003, a new primer system was successfully developed and standardized for the detection of clonally rearranged immunoglobulin (Ig) and T-cell receptor (TCR) genes. This study was a prospective analysis of Ig heavy chain (IgH) and TCR-γ gene rearrangements using the new primer system and endoscopic biopsy specimens from patients with suspected primary gastric lymphoma (PGL). Our study revealed that the detection of monoclonal IgH gene rearrangements is useful for the diagnosis of PGL and for differentiating between PGL and gastric linitis plastica. Monoclonal IgH gene rearrangements may be associated with PGL staging. The sensitivity and the specificity of IgH gene rearrangements for the diagnosis of PGL were 66.7% and 96.4%, respectively.
