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World J Gastroenterol. Sep 14, 2013; 19(34): 5633-5644
Published online Sep 14, 2013. doi: 10.3748/wjg.v19.i34.5633
Published online Sep 14, 2013. doi: 10.3748/wjg.v19.i34.5633
Protective effect of naringenin on acetic acid-induced ulcerative colitis in rats
Salim S Al-Rejaie, Hatem M Abuohashish, Mihir Y Parmar, Mohammed M Ahmed, Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh 11544, Saudi Arabia
Maher M Al-Enazi, Department of Medical Laboratory Sciences, College of Applied Medical Sciences, Salman bin Abdulaziz University, Al-Kharj 11942, Saudi Arabia
Abdullah H Al-Assaf, Department of Science and Nutrition, College of Food and Agricultural Sciences, King Saud University, Riyadh 11544, Saudi Arabia
Author contributions: Al-Rejaie SS, Abuohashish HM, Ahmed MM and Al-Assaf AH designed the research; Abuohashish HM, Parmar MY, Al-Assaf AH and Ahmed MM performed the research; Al-Rejaie SS, Abuohashish HM, Al-Enazi MM and Ahmed MM analyzed the data and wrote the paper.
Supported by The Deanship of Scientific Research at King Saud University for its funding this research through the research group project, No. RGP-VPP-266
Correspondence to: Salim S Al-Rejaie, Associate Professor of Pharmacology and Toxicology, Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, PO Box 55760, Riyadh 11544, Saudi Arabia. rejaie@ksu.edu.sa
Telephone: + 966-5-55992003 Fax: + 966-1-4679014
Received: February 6, 2013
Revised: June 9, 2013
Accepted: June 18, 2013
Published online: September 14, 2013
Revised: June 9, 2013
Accepted: June 18, 2013
Published online: September 14, 2013
Core Tip
Core tip: Inflammatory bowel disease (IBD), consisting of Crohn’s disease (CD) and ulcerative colitis (UC), results in substantial morbidity and is difficult to treat. New strategies for adjunct therapies are needed. Systemic corticosteroids are highly effective at inducing clinical remission in cases of acute exacerbation of CD and UC; however, their use is limited by their frequent and sometimes severe side effects. Results of present study revealed that, naringenin has protective effects against acetic acid-induced UC by inhibiting inflammatory and oxidative bio-markers. Thus, it may pose promising outcomes for future clinical usage as a natural non-toxic effective supplement in IBD.