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World J Gastroenterol. Sep 7, 2013; 19(33): 5454-5463
Published online Sep 7, 2013. doi: 10.3748/wjg.v19.i33.5454
Published online Sep 7, 2013. doi: 10.3748/wjg.v19.i33.5454
Biliary phosphatidylcholine and lysophosphatidylcholine profiles in sclerosing cholangitis
Annika Gauss, Robert Ehehalt, Karl-Heinz Weiss, Yvonne Schaefer, Petra Kloeters-Plachky, Adolf Stiehl, Wolfgang Stremmel, Peter Sauer, Daniel Nils Gotthardt, Gastroenterology and Hepatology Unit, Department of Internal Medicine, University Hospital Heidelberg, 69120 Heidelberg, Germany
Wolf-Dieter Lehmann, Gerhard Erben, Department of Spectroscopy, German Cancer Research Center, 69120 Heidelberg, Germany
Author contributions: Gauss A and Gotthardt DN designed the research; Gauss A, Gotthardt DN, Schaefer Y, Erben G and Kloeters-Plachky P performed the research; Lehmann WD, Sauer P, Stiehl A, Ehehalt R, Weiss KH and Stremmel W contributed to analysis and interpretation of data; Gauss A and Gotthardt DN wrote the paper; Gauss A, Ehehalt R, Lehmann WD, Erben G, Weiss KH, Schaefer Y, Kloeters-Plachky P, Stiehl A, Stremmel W, Sauer P and Gotthardt DN revised the manuscript critically for important intellectual content.
Supported by A Grant from Deutsche Forschungsgemeinschaft (DFG)
Correspondence to: Annika Gauss, MD, Gastroenterology and Hepatology Unit, Department of Internal Medicine, University Hospital Heidelberg, INF 410, Heidelberg 69120, Germany. annika.gauss@med.uni-heidelberg.de
Telephone: +49-6221-5638865 Fax: +49-6221-565255
Received: March 31, 2013
Revised: June 8, 2013
Accepted: July 17, 2013
Published online: September 7, 2013
Revised: June 8, 2013
Accepted: July 17, 2013
Published online: September 7, 2013
Core Tip
Core tip: Based on the idea that unfavorable alterations of biliary phospholipids might play a role in the pathogenesis of sclerosing cholangitis, phosphatidylcholine (PC) and lysophosphatidylcholine (LPC) species profiles were analyzed in endoscopically-acquired intrahepatic bile using nano-electrospray ionization tandem mass spectrometry. The examination of specimens from 14 patients with primary sclerosing cholangitis, 10 patients with secondary sclerosing cholangitis, 11 patients with choledocholithiasis/no biliary disease and 6 patients with cholangiocellular carcinoma revealed strikingly similar PC and LPC species patterns, implicating at the most a minor role of biliary phospholipid changes in sclerosing cholangitis.