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World J Gastroenterol. Sep 7, 2013; 19(33): 5446-5453
Published online Sep 7, 2013. doi: 10.3748/wjg.v19.i33.5446
Published online Sep 7, 2013. doi: 10.3748/wjg.v19.i33.5446
HBV endemicity in Mexico is associated with HBV genotypes H and G
Sonia Roman, Arturo Panduro, Department of Molecular Biology in Medicine, Civil Hospital of Guadalajara, “Fray Antonio Alcalde”, and Health Sciences Center, University of Guadalajara, Guadalajara 44280, Jalisco, Mexico
Author contributions: Roman S and Panduro A contributed equally to this paper.
Supported by National Council of Science and Technology (CONACYT-FONDO SECTORIAL, Mexico), Grant No. Salud-2010-1-139085, to Roman S; and Jalisco State Council of Science and Technology (COECYTJAL-Universidad de Guadalajara, Guadalajara, Jalisco, Mexico), Grant No. 2009-1-06-2009-431, to Panduro A
Correspondence to: Arturo Panduro, MD, PhD, Department of Molecular Biology in Medicine, Civil Hospital of Guadalajara, “Fray Antonio Alcalde”, and Health Sciences Center, University of Guadalajara, Guadalajara 44280, Jalisco, Mexico. apanduro@prodigy.net.mx
Telephone: +52-33-36147743 Fax: +52-33-36147743
Received: May 7, 2013
Revised: June 15, 2013
Accepted: July 18, 2013
Published online: September 7, 2013
Revised: June 15, 2013
Accepted: July 18, 2013
Published online: September 7, 2013
Core Tip
Core tip: Molecular, clinical, geographical and ethnicity evidence are characteristics that define any hepatitis B virus (HBV) genotype. All of these features are there for HBV genotype H, which is most predominant in Mexico, but not in Central America. Likewise, HBV genotype G has unique molecular characteristics and a similar route of transmission among those infected with this viral genotype, but it lacks a geographic origin. To date, despite the high prevalence of HBV genotype G cases from the Americas, especially among Mexicans, the limited number of complete sequences hinders further investigation to establish a hypothesis of an Amerindian origin.