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World J Gastroenterol. Sep 7, 2013; 19(33): 5439-5445
Published online Sep 7, 2013. doi: 10.3748/wjg.v19.i33.5439
Published online Sep 7, 2013. doi: 10.3748/wjg.v19.i33.5439
Epigenetics of hepatocellular carcinoma: Role of microRNA
Sharad Khare, Qiong Zhang, Jamal A Ibdah, Division of Gastroenterology and Hepatology, Department of Internal Medicine, University of Missouri, Columbia, MO 65212, United States
Sharad Khare, Harry S Truman Memorial Veterans’ Hospital, Columbia, MO 65201, United States
Author contributions: Khare S conceived the topic, reviewed the literature; Khare S, Zhang Q and Ibdah JA wrote the manuscript; Ibdah JA contributed to the analyzed and edited the manuscript, and provided overall intellectual input into the design and execution of the manuscript.
Supported by VA Merit Award, project ID 1171590; NCI Cancer Prevention RO3 Grant, CA150081-03 to Khare S; Raymond E and Vaona H Peck Chair in Cancer Research to Ibdah JA
Correspondence to: Jamal A Ibdah, MD, PhD, Professor, Director, Division of Gastroenterology and Hepatology, Department of Internal Medicine, University of Missouri, 319 jesse hall, Columbia, MO 65212, United States. ibdahj@health.missouri.edu
Telephone: +1-573-8827349 Fax: +1-573-8844595
Received: May 14, 2013
Revised: July 3, 2013
Accepted: July 19, 2013
Published online: September 7, 2013
Revised: July 3, 2013
Accepted: July 19, 2013
Published online: September 7, 2013
Core Tip
Core tip: This review provides the relationship between microRNA (miR) and hepatocellular carcinoma and speculates on the progress that will be achieved through ongoing research. A research effort to identify genetic polymorphisms associated with cancer is emphasized. The review highlights that miR-based therapeutics, and diagnostic and prognostic systems should be used for patients.