Review
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World J Gastroenterol. Aug 28, 2013; 19(32): 5227-5237
Published online Aug 28, 2013. doi: 10.3748/wjg.v19.i32.5227
Risk factors for local recurrence following neoadjuvant chemoradiotherapy for rectal cancers
Jia-Yuan Peng, Zhong-Nan Li, Yu Wang
Jia-Yuan Peng, Zhong-Nan Li, Yu Wang, Department of Surgery, Shanghai Sixth People’s Hospital, Shanghai Jiao Tong University, Shanghai 200233, China
Author contributions: Peng JY and Li ZN contributed equally to this work; Peng JY reviewed the literature and wrote the article; Li ZN contributed to the analysis and interpretation of the data; Wang Y designed the review and revised the article; all authors have read and approved the final version to be published.
Correspondence to: Yu Wang, Professor, Department of Surgery, Shanghai Sixth People’s Hospital, Shanghai Jiao Tong University, 600 Yishan Road, Shanghai 200233, China. wangyu11122@126.com
Telephone: +86-21-64361349 Fax: +86-21-64368920
Received: April 5, 2013
Revised: July 3, 2013
Accepted: July 17, 2013
Published online: August 28, 2013
Core Tip

Core tip: This review identifies the distinctive risk factors associated with local recurrence (LR) in patients with rectal cancer receiving neoadjuvant therapy. These factors are different from the traditional risk factors seen in patients treated with surgery and/or adjuvant therapy alone. The clinical significance of these risk factors is clarified in detail. To our knowledge, no reviews concerning this topic have been published. The present manuscript might help to understand the origin of LR following neoadjuvant chemoradiotherapy and may receive attention from investigators devoted to improving the prognosis of rectal cancer.