Published online Aug 14, 2013. doi: 10.3748/wjg.v19.i30.5006
Revised: June 4, 2013
Accepted: June 8, 2013
Published online: August 14, 2013
Core tip: The genomic barcoding technology was recently developed to increase the accuracy of genome analysis, and has facilitated the identification of origin-specific genomic regions of both eukaryotic and prokaryotic lifeforms. In this study, we applied the genomic barcode imaging approach to screen for pathogenicity islands (PAIs) in Helicobacter pylori using the six strains for which the complete genome sequences have been published and performing comparison to a common Enterobacter species. Bioinformatic-based functional analysis not only provided proof-of-principle (identifying the known cag-PAI) but also identified a novel PAI (designated as tsf3-PAI).