Published online Aug 7, 2013. doi: 10.3748/wjg.v19.i29.4718
Revised: March 20, 2013
Accepted: April 10, 2013
Published online: August 7, 2013
Core tip: Clinical trials of probiotics for gut health often utilize intestinal transit time (ITT) as a measure of clinical success although treatment effects are not consistent across studies. We performed the first systematic review and meta-analysis of randomized controlled trials to investigate the efficacy of probiotic supplementation on ITT in adults and to identify factors that influence these outcomes. Overall, short-term probiotic supplementation decreases ITT with consistently greater treatment effects identified in constipated or older adults and with certain probiotic strains.