Published online Aug 7, 2013. doi: 10.3748/wjg.v19.i29.4671
Revised: April 18, 2013
Accepted: May 7, 2013
Published online: August 7, 2013
Core tip: Among somatic stem cells, those residing in the intestine represent a fascinating and poorly explored research field. Aim of the present review is to delve into the mechanisms that regulate the delicate equilibrium through which intestinal stem cells orchestrate intestinal architecture, integrating signals from the surrounding niche and supports a model whereby distinct cell populations facilitate homeostatic vs injury-induced regeneration.