Brief Article
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World J Gastroenterol. Jul 28, 2013; 19(28): 4504-4510
Published online Jul 28, 2013. doi: 10.3748/wjg.v19.i28.4504
Neurotensin receptor 1 overexpression in inflammatory bowel diseases and colitis-associated neoplasia
Xianyong Gui, Shuhong Liu, Yuchu Yan, Zuhua Gao
Xianyong Gui, Shuhong Liu, Yuchu Yan, Zuhua Gao, Calgary Laboratory Services and Department of Pathology and Laboratory Medicine, University of Calgary, Calgary, Alberta T2N 2T9, Canada
Author contributions: Gui X is the guarantor of the work as well as the main/lead researcher who was instrumental in the design, planning, selecting tissue samples, conducting the study, data review and analysis of the results, and writing the manuscript; Liu S was the major contributor to the laboratory work; Yan Y assisted with the laboratory work; Gao Z contributed partly to the results review/analysis, comments, and review of the manuscript.
Supported by Calgary Laboratory Services Internally Supported Research, RS09-533
Correspondence to: Xianyong Gui, MD, PhD, Calgary Laboratory Services and Department of Pathology and Laboratory Medicine, University of Calgary, 1403-29 Street NW, Calgary, Alberta T2N 2T9, Canada. xsean.gui@cls.ab.ca
Telephone: +1-403-9448507 Fax: +1-403-9444748
Received: December 3, 2012
Revised: March 23, 2013
Accepted: April 13, 2013
Published online: July 28, 2013
Processing time: 238 Days and 6 Hours
Core Tip

Core tip: Neurotensin receptor 1 (NTSR1) in colonic epithelial cells is overexpressed in inflammatory bowel diseases, in a stepwise fashion with the sequential progress from inflammation to low-grade dysplasia, high-grade dysplasia, and carcinoma. Both colitis-associated and sporadic dysplasia/carcinoma showed a similar pattern of NTSR1 overexpression. NTSR1 could be a potential pharmacological target in the treatment of inflammatory bowel diseases and prevention of colitis-associated neoplasia.