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World J Gastroenterol. Jul 21, 2013; 19(27): 4356-4362
Published online Jul 21, 2013. doi: 10.3748/wjg.v19.i27.4356
Published online Jul 21, 2013. doi: 10.3748/wjg.v19.i27.4356
Gastrointestinal side effects in children with Wilson's disease treated with zinc sulphate
Anna Wiernicka, Wojciech Jańczyk, Maciej Dądalski, Piotr Socha, Department of Gastroenterology, Hepatology and Malnutrition, the Children’s Memorial Health Institute, 04-730 Warsaw, Poland
Yesim Avsar, Hartmut Schmidt, Klinik und Poliklinik für Transplantationsmedizin, University Hospital of Muenster, 48149 Muenster, Germany
Author contributions: Socha P designed the study; Wiernicka A was responsible for the review of the literature, interpretation of data and initial preparation of the paper; Dądalski M analyzed the data; Schmidt H performed the genetic analysis; Jańczyk W and Avsar Y were involved in editing the manuscript; Avsar Y and Socha P prepared final version of the manuscript.
Correspondence to: Piotr Socha, Professor, Department of Gastroenterology, Hepatology and Malnutrition, the Children’s Memorial Health Institute, Al. Dzieci Polskich 20, 04-730 Warsaw, Poland. p.socha@czd.pl
Telephone: +48-22-8157384 Fax: +48-22-8157382
Received: October 15, 2012
Revised: February 6, 2013
Accepted: March 6, 2013
Published online: July 21, 2013
Revised: February 6, 2013
Accepted: March 6, 2013
Published online: July 21, 2013
Core Tip
Core tip: The present study demonstrates a considerably higher rate and severity of gastrointestinal adverse effects secondary to zinc sulphate therapy in pediatric patients as previously reported. A total of 40% of our treated patients experienced gastrointestinal symptoms, of which the more severe cases were associated with endoscopically evident gastric ulcerations and erosions. Furthermore it was shown, that proton pump inhibitors were not effective in treating patients with severe zinc associated gastrointestinal side effects, requiring a switch to an alternative treatment regimen.