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World J Gastroenterol. Jul 21, 2013; 19(27): 4325-4333
Published online Jul 21, 2013. doi: 10.3748/wjg.v19.i27.4325
Published online Jul 21, 2013. doi: 10.3748/wjg.v19.i27.4325
Phytoestrogens/insoluble fibers and colonic estrogen receptor β: Randomized, double-blind, placebo-controlled study
Mariabeatrice Principi, Alfredo Di Leo, Maria Pricci, Maria Principia Scavo, Raffaella Guido, Sabina Tanzi, Antonio Pisani, Michele Barone, Gastroenterology Unit, Department of Emergency and Organ Transplantation, University of Bari, 70124 Bari, Italy
Domenico Piscitelli, Pathology Unit, Department of Emergency and Organ Transplantation, University of Bari, 70124 Bari, Italy
Enzo Ierardi, Gastroenterology Unit, Department of Medical Sciences, University of Foggia, 71100 Foggia, Italy
Maria Cristina Comelli, R and D, CMD Pharma Limited, London SW1V4BJ, United Kingdom
Author contributions: Di Leo A and Comelli MC contributed formulation and invention of the active dietary intervention and designed research; Pricci M, Scavo MP, Guido R, Tanzi S, Piscitelli D and Pisani A performed research; Principi M, Ierardi E and Barone M analyzed data and wrote the paper.
Supported by Wholly granted from R and D, CMD Pharma Limited, United Kingdom
Correspondence to: Alfredo Di Leo, Professor, Chief of Gastroenterology Unit, Department of Emergency and Organ Transplantation, University of Bari, Piazza Giulio Cesare 11, 70124 Bari, Italy. b.principi@gmail.com
Telephone: +39-80-5502577 Fax: +39-80-5593251
Received: February 8, 2013
Revised: April 18, 2013
Accepted: May 8, 2013
Published online: July 21, 2013
Revised: April 18, 2013
Accepted: May 8, 2013
Published online: July 21, 2013
Core Tip
Core tip: Active dietary intervention, a mixture of phytoestrogens and insoluble fibers, was administered in patients with sporadic colonic adenomas in a randomized, double-blind placebo-controlled trial. Dietary supplementation induced an increase in estrogen receptor (ER)-β protein and the ER-β/ER-α ratio with a general trend towards an increase in epithelial proliferation and apoptosis. These results, even if limited by the small number of subjects and short period of dietary supplementation, suggest the possibility of an interaction with epithelial apoptosis by means of mediating ER-β levels.