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World J Gastroenterol. Jul 21, 2013; 19(27): 4289-4299
Published online Jul 21, 2013. doi: 10.3748/wjg.v19.i27.4289
Published online Jul 21, 2013. doi: 10.3748/wjg.v19.i27.4289
miR-20b, miR-98, miR-125b-1*, and let-7e* as new potential diagnostic biomarkers in ulcerative colitis
Mehmet Coskun, Jacob Tveiten Bjerrum, Jakob Benedict Seidelin, Ole Haagen Nielsen, Department of Gastroenterology, Medical Section, Herlev Hospital, University of Copenhagen, DK-2730 Herlev, Denmark
Mehmet Coskun, Jacob Tveiten Bjerrum, Jørgen Olsen, Department of Cellular and Molecular Medicine, the Panum Institute, University of Copenhagen, DK-2200 Copenhagen, Denmark
Jakob Benedict Seidelin, Department of Internal Medicine I, University of Copenhagen, Bispebjerg Hospital, DK-2400 Copenhagen NV, Denmark
Jesper Thorvald Troelsen, Department of Science, Systems, and Models, Roskilde University, DK-4000 Roskilde, Denmark
Author contributions: Coskun M and Bjerrum JT performed the experiments and data analysis, wrote the manuscript, and wrote the final revision of the article; Troelsen JT provided with analytical tools, intellectual input and advice; Olsen J provided with reagents and human tissue; Seidelin JB and Nielsen OH contributed to the conceptual design, drafting of the manuscript and revising it critically for important intellectual content; all authors approved the final submitted manuscript.
Supported by Fonden til Lægevidenskabens Fremme (the AP Møller Foundation); the Family Erichsen Memorial Foundation; and the Foundation of Aase and Ejnar Danielsen
Correspondence to: Mehmet Coskun, PhD, Department of Gastroenterology, Medical Section, Herlev Hospital, University of Copenhagen, Herlev Ringvej 75, DK-2730 Herlev, Denmark. mehmet.coskun@regionh.dk
Telephone: +45-38-683421 Fax: +45-38-684009
Received: January 11, 2013
Revised: April 15, 2013
Accepted: May 9, 2013
Published online: July 21, 2013
Revised: April 15, 2013
Accepted: May 9, 2013
Published online: July 21, 2013
Core Tip
Core tip: This study contributes to the current knowledge on the putative role of microRNAs in inflammatory bowel disease pathogenesis, and it provides the first evidence that miR-20b, miR-98, miR-125b-1*, and let-7e* are deregulated in patients with ulcerative colitis. The level of these miRNAs may serve as new potential biomarkers for this chronic disease.