Published online Jul 14, 2013. doi: 10.3748/wjg.v19.i26.4242
Revised: April 3, 2013
Accepted: May 16, 2013
Published online: July 14, 2013
Core tip: BabA encoded by babA2 gene is an outer member protein of Helicobacter pylori (H. pylori), which plays a key role in facilitating bacterial colonization in the stomach. The association between babA2 and H. pylori-related gastroduodenal diseases is still controversial. We summarized a total of 25 case-control articles with 38 studies in this meta-analysis and evaluated the relationship between babA2 and clinical outcomes. The presence of babA2 may contribute to increased risk of peptic ulcer disease (PUD), especially duodenal ulcer, in western countries. In Asians, babA2 genotype only showed a marginal association with PUD risk, which requires further investigation.