Published online Jul 14, 2013. doi: 10.3748/wjg.v19.i26.4214
Revised: May 2, 2013
Accepted: May 8, 2013
Published online: July 14, 2013
Core tip: Low-dose amitriptyline has been used to treat functional gastrointestinal disorders for many years, but the precise mechanism is still not clear. Brain-gut peptides, such as motilin, ghrelin and neuropeptide Y, may regulate gastrointestinal functions. However, evidence indicating the possible effects of amitriptyline on the levels of brain-gut peptides in healthy Chinese volunteers is limited. In this study, we conclude that low-dose amitriptyline can slow orocecal transit time, make the stomach less sensitive and increase the plasma levels of ghrelin and neuropeptide Y. Thus, we recommend the use of low-dose amitriptyline for functional gastrointestinal disorders.