Metabonomic studies of pancreatic cancer response to radiotherapy in a mouse xenograft model using magnetic resonance spectroscopy and principal components analysis

doi:10.3748/wjg.v19.i26.4200

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 19, Issue 26

This Article

Academic Content and Language Evaluation of This Article

Citation of this article

Corresponding Author of This Article

Research Domain of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

Total Article Views (5786)

All Articles published online

The chart showing PDF series, HTML series, Figures (1-3) series, Tables (1-2) series.

Item

Count

PDF

384

HTML

3262

Figures (1-3)

197

Tables (1-2)

131

Sum=3974

Publishing Process of This Article

The chart showing Browse series, Download series.

Item

Count

Browse

861

Download

951

Sum=1812

Jul 14, 2013 (publication date) through Apr 26, 2024

Times Cited of This Article

Times Cited (17)

Journal Information of This Article

Publication Name

World Journal of Gastroenterology

ISSN

1007-9327

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Brief Article

World J Gastroenterol. Jul 14, 2013; 19(26): 4200-4208
Published online Jul 14, 2013. doi: 10.3748/wjg.v19.i26.4200

Metabonomic studies of pancreatic cancer response to radiotherapy in a mouse xenograft model using magnetic resonance spectroscopy and principal components analysis

Xin-Hong He, Wen-Tao Li, Ya-Jia Gu, Bao-Feng Yang, Hui-Wen Deng, Yi-Hua Yu, Wei-Jun Peng

Xin-Hong He, Wen-Tao Li, Ya-Jia Gu, Bao-Feng Yang, Wei-Jun Peng, Department of Radiology, Fudan University Shanghai Cancer Center, Shanghai 200032, China

Hui-Wen Deng, Yi-Hua Yu, Shanghai Key Laboratory of Functional Magnetic Resonance Imaging, Physics Department, East China Normal University, Shanghai 200062, China

Author contributions: He XH performed the majority of the experiments; Li WT, Gu YJ, Yang BF, Deng HW and Yu YH provided vital reagents and analytical tools, and were also involved in editing the manuscript; Peng WJ designed the study and wrote the manuscript.

Supported by The Medical Imageology Special Purpose Foundation of Cancer Hospital/Cancer Institute Fudan University, No. YX200802

Correspondence to: Wei-Jun Peng, MD, Department of Radiology, Fudan University Shanghai Cancer Center, No. 270, Dong’an Road, Shanghai 200032, China. weijunpeng378@gmail.com

Telephone: +86-21-64175590-3430 Fax: +86-21-64433384

Received: December 25, 2012
Revised: March 22, 2013
Accepted: April 27, 2013
Published online: July 14, 2013

Core Tip

Core tip: In the present study, for the first time to our knowledge, high-resolution magic angle spinning proton magnetic resonance spectroscopy and principal components analysis were combined to highlight metabolite profiles of pancreatic cancer after radiotherapy, by analyzing the correlation between radiotherapy effect and metabolic change, and optimizing the therapeutic scheme. The results showed that metabolic profile changes of pancreatic cancer after radiotherapy were closely correlated with therapeutic effect. The outcome of the study is both interesting and beneficial to pathological research, early diagnosis, and therapy evaluation of pancreatic diseases.