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World J Gastroenterol. Jul 14, 2013; 19(26): 4127-4136
Published online Jul 14, 2013. doi: 10.3748/wjg.v19.i26.4127
Published online Jul 14, 2013. doi: 10.3748/wjg.v19.i26.4127
Hugl-1 induces apoptosis in esophageal carcinoma cells both in vitro and in vivo
Jia Song, Xiu-Lan Peng, Meng-Yao Ji, Ming-Hua Ai, Ji-Xiang Zhang, Wei-Guo Dong, Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei Province, China
Author contributions: Song J and Peng XL performed the majority of experiments; Ji MY, Ai MH and Zhang JX provided vital reagents and analytical tools and were also involved in editing the manuscript; Dong WG designed the study and wrote the manuscript.
Supported by The Fundamental Research Funds for the Central Universities, No. 302274546
Correspondence to: Dr. Wei-Guo Dong, Department of Gastroenterology, Renmin Hospital of Wuhan University, Zhidong Zhang Road 99, Wuhan 430060, Hubei Province, China. dwg@whu.edu.cn
Telephone: +86-27-88041911 Fax: +86-27-88042292
Received: February 27, 2013
Revised: April 15, 2013
Accepted: May 8, 2013
Published online: July 14, 2013
Revised: April 15, 2013
Accepted: May 8, 2013
Published online: July 14, 2013
Core Tip
Core tip: In this paper, we constructed a plasmid to express Hugl-1 which has significant homology to the Drosophila tumor suppressor gene lethal giant larvae. The human esophageal squamous cell carcinoma cell line Eca109 was used as the object of study. We found a positive correlation between Hugl-1 expression and cell apoptosis in Eca109 cells both in vitro and in vivo. These data suggest that Hugl-1 is a tumor suppressor gene in esophageal cancer and may provide a novel target for the treatment of esophageal cancer patients.