Copyright
©2013 Baishideng Publishing Group Co., Limited. All rights reserved.
World J Gastroenterol. Jul 7, 2013; 19(25): 4094-4098
Published online Jul 7, 2013. doi: 10.3748/wjg.v19.i25.4094
Published online Jul 7, 2013. doi: 10.3748/wjg.v19.i25.4094
Epstein-Barr virus negative primary hepatic leiomyoma: Case report and literature review
Xian-Zhang Luo, Chang-Sheng Ming, Xiao-Ping Chen, Nian-Qiao Gong, Institute of Organ Transplantation, Department of Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, China
Xian-Zhang Luo, Chang-Sheng Ming, Xiao-Ping Chen, Nian-Qiao Gong, Key Laboratory of the Ministry of Health and Key Laboratory of the Ministry of Education, Wuhan 430030, Hubei Province, China
Author contributions: Luo XZ and Ming CS contributed equally to this work; Gong NQ and Chen XP designed the research; all authors performed the research, analyzed the data, wrote the paper, and approved the final manuscript.
Supported by Grants from the National Natural Science Foundation of China, No. 81072441, to Gong NG; and grants from the National High-Tech Research and Development Program (Program 863) of the Ministry of Science and Technology of China, 2012AA021010, to Ming CS
Correspondence to: Nian-Qiao Gong, MD, PhD, Institute of Organ Transplantation, Department of Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Avenue,Wuhan 430030, Hubei Province, China. nqgong@tjh.tjmu.edu.cn
Telephone: +86-27-83663822 Fax: +86-27-83662892
Received: March 21, 2013
Revised: May 5, 2013
Accepted: May 16, 2013
Published online: July 7, 2013
Revised: May 5, 2013
Accepted: May 16, 2013
Published online: July 7, 2013
Core Tip
Core tip: Primary hepatic leiomyoma is usually found in adult women and is associated with Epstein-Barr virus (EBV) infection. We report the 29th case worldwide in a 48-year-old kidney allograft recipient without EBV infection and extrahepatic tumor. He achieved clinical cure by mass resection. The leiomyoma was positive for α-smooth muscle actin and desmin, and negative for gastrointestinal stromal tumor markers, including CD117, CD34 and DOG1 (discovered on gastrointestinal stromal tumor 1). The tumor was negative for EBV-encoded small RNA. The data indicate that EBV infection is important but neither necessary nor sufficient for development of primary liver leiomyoma.