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World J Gastroenterol. Jul 7, 2013; 19(25): 4031-4038
Published online Jul 7, 2013. doi: 10.3748/wjg.v19.i25.4031
Published online Jul 7, 2013. doi: 10.3748/wjg.v19.i25.4031
Clinical and pathological differences between serum immunoglobulin G4-positive and -negative type 1 autoimmune pancreatitis
Woo Hyun Paik, Ji Kon Ryu, Jin Myung Park, Byeong Jun Song, Joo Kyung Park, Yong-Tae Kim, Department of Internal Medicine, Liver Research Institute, Seoul 110-744, South Korea
Ji Kon Ryu, Division of Gastroenterology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul 110-744, South Korea
Kyoungbun Lee, Department of Pathology, Seoul National University College of Medicine, Seoul 110-744, South Korea
Author contributions: All authors were involved in recruitment of patients and diagnosis of autoimmune pancreatitis; Paik WH and Park JM performed the research and wrote the paper; Ryu JK designed the research, analyzed the data and contributed to the preparation, editing, and final approval of the manuscript; Park JK and Song BJ wrote the paper; Kim YT contributed to the preparation and final approval of the manuscript and conceived the project; Lee KB was involved in re-evaluation of the histology.
Correspondence to: Ji Kon Ryu, MD, PhD, Associate Professor, Division of Gastroenterology, Department of Internal Medicine, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul 110-744, South Korea. jkryu@snu.ac.kr
Telephone: +82-2-20721962 Fax: +82-2-7436701
Received: February 17, 2013
Revised: April 1, 2013
Accepted: April 18, 2013
Published online: July 7, 2013
Revised: April 1, 2013
Accepted: April 18, 2013
Published online: July 7, 2013
Core Tip
Core tip: Type 1 autoimmune pancreatitis (AIP) is one of the immunoglobulin G4 (IgG4)-related diseases and serum IgG4 is known as a useful diagnostic marker. However, the sensitivity of serum IgG4 is variable. The sensitivity of serum IgG4 was not sufficient (68%) in definite type 1 AIP. The demographic findings were not different between SIP and SIN type 1 AIP, but other organ involvement was significantly more common in SIP than in SIN type 1 AIP. High serum IgG4 level was associated with other organ involvement and tissue IgG4 concentration, but did not affect the relapse rate in type 1 AIP.